p-JAK1 (Y1022) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
p-JAK1 (Y1022) Peptide Applications :
Blocking Background :
JAK1 (Janus kinase 1) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events. Alternative Name :
AA960307; C130039L05Rik; JAK1A; JAK1B; Janus kinase 1; Janus kinase 1a. Entrez Gene ID: 3716 Swiss-Prot :
P23458 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide p-JAK1 (Y1022). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS4108 p-JAK1 (Y1022) pAb.
p-JAK1 (Y1022) Peptide Applications :
Blocking Background :
JAK1 (Janus kinase 1) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events. Alternative Name :
AA960307; C130039L05Rik; JAK1A; JAK1B; Janus kinase 1; Janus kinase 1a. Entrez Gene ID: 3716 Swiss-Prot :
P23458 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide p-JAK1 (Y1022). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS4108 p-JAK1 (Y1022) pAb.
Blocking peptide available as BS4108PP