p-BIK/ NBK (T33) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
p-BIK/ NBK (T33) Peptide Applications :
Blocking Background :
The Bcl-2 gene was isolated at the chromosomal breakpoint of t-bearing follicular B cell lymphomas. Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. A protein designated Bax p21 (i.e., Bcl-associated X protein) has extensive amino acid homology with Bcl-2 and both homodimerizes and heterodimerizes with Bcl-2. Overexpression of Bax accelerates apoptotic death. Natural born killer (NBK), also known as Bik, is a protein that is functionally related to Bax, although the two proteins share very little sequence homology. NBK does not contain the conserved Bcl-2 homology domains (BH domains) characteristic of the Bcl-2 family. It does however, share nine amino acids with Bax in a region designated BH3, which may be the critical determinant for the protein’s death-promoting activities. Phosphorylation of NBK at Ser35 and Thr33 is required for eliciting efficient apoptotic activity. Alternative Name :
Apoptosis inducer NBK; BBC1; Bcl-2-interacting killer; BCL2 interacting killer; bhikhari; BIK; Bik-like killer protein; BIK; BIP 1; BIP1; BP 4; BP4; cb 60; NBK; Swiss-Prot :
Q13323 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide p-BIK/ NBK (T33). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS4215 p-BIK/ NBK (T33) pAb.
p-BIK/ NBK (T33) Peptide Applications :
Blocking Background :
The Bcl-2 gene was isolated at the chromosomal breakpoint of t-bearing follicular B cell lymphomas. Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. A protein designated Bax p21 (i.e., Bcl-associated X protein) has extensive amino acid homology with Bcl-2 and both homodimerizes and heterodimerizes with Bcl-2. Overexpression of Bax accelerates apoptotic death. Natural born killer (NBK), also known as Bik, is a protein that is functionally related to Bax, although the two proteins share very little sequence homology. NBK does not contain the conserved Bcl-2 homology domains (BH domains) characteristic of the Bcl-2 family. It does however, share nine amino acids with Bax in a region designated BH3, which may be the critical determinant for the protein’s death-promoting activities. Phosphorylation of NBK at Ser35 and Thr33 is required for eliciting efficient apoptotic activity. Alternative Name :
Apoptosis inducer NBK; BBC1; Bcl-2-interacting killer; BCL2 interacting killer; bhikhari; BIK; Bik-like killer protein; BIK; BIP 1; BIP1; BP 4; BP4; cb 60; NBK; Swiss-Prot :
Q13323 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide p-BIK/ NBK (T33). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS4215 p-BIK/ NBK (T33) pAb.
Blocking peptide available as BS4215PP