Product Name :
p-PI3K p85 (Y467)/p55 (Y199) Peptide Applications :
Blocking Background :
The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 alpha). p85 alpha is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Alternative Name :
GRB1; p50 alpha; p55 alpha; p85 alpha; p85; P85A; Phosphatidylinositol 3 kinase associated p 85 alpha; Phosphatidylinositol 3 kinase associated p85 alpha; Phosphatidylinositol 3 kinase regulatory 1; Phosphatidylinositol 3 kinase regulatory alpha subunit; Phosphatidylinositol 3 kinase; regulatory subunit; polypeptide 1 (p85 alpha); Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; Phosphatidylinositol 3-kinase regulatory subunit alpha; Phosphoinositide 3 kinase re Swiss-Prot :
P27986/Q92569 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide p-PI3K p85 (Y467)/p55 (Y199). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS4605 p-PI3K p85 (Y467)/p55 (Y199) pAb.

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Blocking peptide available as BS4605PP