p-Dok-2 (Y299) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
p-Dok-2 (Y299) Peptide Applications :
Blocking Background :
Dok-1 associates with the Ras GTPase activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that p62 Dok-1 is a substrate of the constitutive tyrosine kinase activity of p210 Bcr-Abl, a fusion protein caused by the t(9;22) translocation and associated with chronic myelogenous leukemia. Dok-1, as well as the tyrosine kinase substrates IRS-1 and Cas, is a member of a class of “docking” proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 is suspected to be the substrate phosphorylated in response to stimulation by a number of growth factors, including PDGF, VEGF, insulin and IGF. Dok-2 (also designated p56 Dok) has also been identified as a potential mediator of the effects of p210 Bcr-Abl. Alternative Name :
Docking protein 2; Downstream of tyrosine kinase 2; p56(dok-2); DOK2 Swiss-Prot :
O60496 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide p-Dok-2 (Y299). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS4786 p-Dok-2 (Y299) pAb.
p-Dok-2 (Y299) Peptide Applications :
Blocking Background :
Dok-1 associates with the Ras GTPase activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that p62 Dok-1 is a substrate of the constitutive tyrosine kinase activity of p210 Bcr-Abl, a fusion protein caused by the t(9;22) translocation and associated with chronic myelogenous leukemia. Dok-1, as well as the tyrosine kinase substrates IRS-1 and Cas, is a member of a class of “docking” proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 is suspected to be the substrate phosphorylated in response to stimulation by a number of growth factors, including PDGF, VEGF, insulin and IGF. Dok-2 (also designated p56 Dok) has also been identified as a potential mediator of the effects of p210 Bcr-Abl. Alternative Name :
Docking protein 2; Downstream of tyrosine kinase 2; p56(dok-2); DOK2 Swiss-Prot :
O60496 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide p-Dok-2 (Y299). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS4786 p-Dok-2 (Y299) pAb.
Blocking peptide available as BS4786PP