p-mTOR (S2448) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
p-mTOR (S2448) Peptide Applications :
Blocking Background :
mTOR, or FKBP12-rapamycin associated protein (FRAP), is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. In rat, it is a 245-kDa protein (symbolized RAFT1) with significant homology to the Saccharomyces cerevisiae protein TOR1 and has been shown to associate with the immunophilin FKBP12 in a rapamycin-dependent fashion. The FKBP12-rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways involved in G1 progression in several cell types, as well as in yeast. The binding of FRAP to FKBP12-rapamycin correlated with the ability of these ligands to inhibit cell cycle progression. Alternative Name :
Raptor; P150 target of rapamycin (TOR)-scaffold protein; RAPTOR; KIAA1303 Swiss-Prot :
P42345 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide p-mTOR (S2448). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS5026 p-mTOR (S2448) pAb.
p-mTOR (S2448) Peptide Applications :
Blocking Background :
mTOR, or FKBP12-rapamycin associated protein (FRAP), is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. In rat, it is a 245-kDa protein (symbolized RAFT1) with significant homology to the Saccharomyces cerevisiae protein TOR1 and has been shown to associate with the immunophilin FKBP12 in a rapamycin-dependent fashion. The FKBP12-rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways involved in G1 progression in several cell types, as well as in yeast. The binding of FRAP to FKBP12-rapamycin correlated with the ability of these ligands to inhibit cell cycle progression. Alternative Name :
Raptor; P150 target of rapamycin (TOR)-scaffold protein; RAPTOR; KIAA1303 Swiss-Prot :
P42345 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide p-mTOR (S2448). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS5026 p-mTOR (S2448) pAb.
Blocking peptide available as BS5026PP