NBL1 Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
NBL1 Peptide Applications :
Blocking Background :
The DAN (differential screening-selected gene aberrative in neuroblastoma) protein family contains antagonists of bone morphogenetic protein (BMP) signaling that are expressed in the neural crest. All family members are secreted proteins that act as BMP antagonists in embryonic explants and are expressed in the proximal airway epithelium of the lung during embryonic development. This family includes the head-inducing factor Cerberus, the dorsaling factor gremlin and the tumor suppressor DAN. DAN, also known as zinc finger protein DAN, NO3, DAND1 or neuroblastoma suppressor of tumorigenicity 1 (NBL1), is a secreted protein containing one C-terminal cysteine knot-like (CTCK) domain. It is produced in small neurons of the dorsal root ganglion and its expression is activated by MATH-1. In addition to antagonizing BMP signaling, DAN also antagonizes the action of TGFβ. DAN is a possible tumor suppressor for human neuroblastoma; defects may result in or contribute to its progression. DAN may also be a neuromodulator in inflammatory pain. Alternative Name :
Neuroblastoma suppressor of tumorigenicity 1; DAN domain family member 1; Protein N03; Zinc finger protein DAN; DAN; DAND1 Swiss-Prot :
P41271 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide NBL1. (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS5694 NBL1 pAb.
NBL1 Peptide Applications :
Blocking Background :
The DAN (differential screening-selected gene aberrative in neuroblastoma) protein family contains antagonists of bone morphogenetic protein (BMP) signaling that are expressed in the neural crest. All family members are secreted proteins that act as BMP antagonists in embryonic explants and are expressed in the proximal airway epithelium of the lung during embryonic development. This family includes the head-inducing factor Cerberus, the dorsaling factor gremlin and the tumor suppressor DAN. DAN, also known as zinc finger protein DAN, NO3, DAND1 or neuroblastoma suppressor of tumorigenicity 1 (NBL1), is a secreted protein containing one C-terminal cysteine knot-like (CTCK) domain. It is produced in small neurons of the dorsal root ganglion and its expression is activated by MATH-1. In addition to antagonizing BMP signaling, DAN also antagonizes the action of TGFβ. DAN is a possible tumor suppressor for human neuroblastoma; defects may result in or contribute to its progression. DAN may also be a neuromodulator in inflammatory pain. Alternative Name :
Neuroblastoma suppressor of tumorigenicity 1; DAN domain family member 1; Protein N03; Zinc finger protein DAN; DAN; DAND1 Swiss-Prot :
P41271 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide NBL1. (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS5694 NBL1 pAb.
Blocking peptide available as BS5694PP