DNA pol ε 2 Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
DNA pol ε 2 Peptide Applications :
Blocking Background :
DNA replication, recombination and repair, all of which are necessary for genome stability, require the presence of exonucleases. In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches. Exonucleases involved in these processes include DNA polymerases, including DNA pol δ and ε. DNA pol δ consists of two subunits-p125 which interacts directly with the sliding DNA clamp protein PCNA, and p50. DNA pol δ can be regulated by cell cycle proteins. DNA pol ε is a multiple subunit enzyme, the catalytic subunit of which is encoded by the POL2 gene. The exact reactions catalyzed by DNA pol δ and ε on leading and lagging strands have not yet been elucidated. Alternative Name :
DNA polymerase epsilon subunit 2; DNA polymerase II subunit 2; DNA polymerase epsilon subunit B; POLE2; DPE2; DNA pol ε2; DNA pol εB; DNA pol ε B; DNA polε2; DNApolε2; DNA polεB; DNApolεB; Swiss-Prot :
P56282 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide DNA pol ε 2. (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS5700 DNA pol ε 2 pAb.
DNA pol ε 2 Peptide Applications :
Blocking Background :
DNA replication, recombination and repair, all of which are necessary for genome stability, require the presence of exonucleases. In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches. Exonucleases involved in these processes include DNA polymerases, including DNA pol δ and ε. DNA pol δ consists of two subunits-p125 which interacts directly with the sliding DNA clamp protein PCNA, and p50. DNA pol δ can be regulated by cell cycle proteins. DNA pol ε is a multiple subunit enzyme, the catalytic subunit of which is encoded by the POL2 gene. The exact reactions catalyzed by DNA pol δ and ε on leading and lagging strands have not yet been elucidated. Alternative Name :
DNA polymerase epsilon subunit 2; DNA polymerase II subunit 2; DNA polymerase epsilon subunit B; POLE2; DPE2; DNA pol ε2; DNA pol εB; DNA pol ε B; DNA polε2; DNApolε2; DNA polεB; DNApolεB; Swiss-Prot :
P56282 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide DNA pol ε 2. (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS5700 DNA pol ε 2 pAb.
Blocking peptide available as BS5700PP