Dishevelled 3 Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
Dishevelled 3 Peptide Applications :
Blocking Background :
Mammalian homologs of the Drosophila dishevelled (Dsh) gene have been identified, including Dvl-1, Dvl-2 and Dvl-3. The mammalian dishevelled proteins contain three homologous domains, two of which are unrelated to any other known protein. The third region is homologous to the discs-large homology domain of Drosophila discs-large-1, a tumor suppressor protein. Like their Drosophila counterpart, the dishevelled proteins are thought to be in-volved in embryogenesis. Overexpression of Dvl-1 has been shown to inhibit the phosphorylation of tau by GSK-3b. This finding may prove to be important in Alzheimer’s studies, which have shown that tau is hyperphosphorylated. In Drosophila, Dsh is a component of the frizzled signaling pathway. Both mammalian dishevelled and frizzled proteins are components of the Wnt signalling pathway. Alternative Name :
Segment polarity protein dishevelled homolog DVL-3; Dishevelled-3; Dishevelled3; DSH homolog 3; DVL3; KIAA0208 Swiss-Prot :
Q92997 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Dishevelled 3. (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS5705 Dishevelled 3 pAb.
Dishevelled 3 Peptide Applications :
Blocking Background :
Mammalian homologs of the Drosophila dishevelled (Dsh) gene have been identified, including Dvl-1, Dvl-2 and Dvl-3. The mammalian dishevelled proteins contain three homologous domains, two of which are unrelated to any other known protein. The third region is homologous to the discs-large homology domain of Drosophila discs-large-1, a tumor suppressor protein. Like their Drosophila counterpart, the dishevelled proteins are thought to be in-volved in embryogenesis. Overexpression of Dvl-1 has been shown to inhibit the phosphorylation of tau by GSK-3b. This finding may prove to be important in Alzheimer’s studies, which have shown that tau is hyperphosphorylated. In Drosophila, Dsh is a component of the frizzled signaling pathway. Both mammalian dishevelled and frizzled proteins are components of the Wnt signalling pathway. Alternative Name :
Segment polarity protein dishevelled homolog DVL-3; Dishevelled-3; Dishevelled3; DSH homolog 3; DVL3; KIAA0208 Swiss-Prot :
Q92997 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Dishevelled 3. (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS5705 Dishevelled 3 pAb.
Blocking peptide available as BS5705PP