HLA-DOB Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
HLA-DOB Peptide Applications :
Blocking Background :
Peptide (antigen) binding to major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC II-Ig dimers and by the activity of MHC molecules HLA-DM and -DO. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. Alternative Name :
HLA class II histocompatibility antigen, DO beta chain; MHC class II antigen DOB; HLA-DOβ; HLA-DO beta Swiss-Prot :
P13765 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide HLA-DOB. (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS5758 HLA-DOB pAb.
HLA-DOB Peptide Applications :
Blocking Background :
Peptide (antigen) binding to major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC II-Ig dimers and by the activity of MHC molecules HLA-DM and -DO. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. Alternative Name :
HLA class II histocompatibility antigen, DO beta chain; MHC class II antigen DOB; HLA-DOβ; HLA-DO beta Swiss-Prot :
P13765 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide HLA-DOB. (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS5758 HLA-DOB pAb.
Blocking peptide available as BS5758PP