SERPINB7 Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
SERPINB7 Peptide Applications :
Blocking Background :
Megsin, also designated SerpinB7 and TP55, is a 380 amino acid cytoplasmic protein that is predominantly expressed in mesangial cells, which play an important role in maintaining glomerular structure and function. As a member of the serpin family, megsin is a serine protesase inhibitor which potentially inactivate MMP-2, MMP-9 and plasmin, proteins that are notably responsible for degradation of extracellular matrix. Overexpression of megsin results in an increase in number of mesangial cells and therefore a progressive mesangial matrix expansion, which is accompanied by immune complex deposition. This finding suggests that megsin significantly influences the role of mesangial cells in renal structure and is likely implicated in a variety of nephropathies. Alternative Name :
Serpin B7; Serpin-B7; Megsin; TP55 Swiss-Prot :
O75635 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide SERPINB7. (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS5794 SERPINB7 pAb.
SERPINB7 Peptide Applications :
Blocking Background :
Megsin, also designated SerpinB7 and TP55, is a 380 amino acid cytoplasmic protein that is predominantly expressed in mesangial cells, which play an important role in maintaining glomerular structure and function. As a member of the serpin family, megsin is a serine protesase inhibitor which potentially inactivate MMP-2, MMP-9 and plasmin, proteins that are notably responsible for degradation of extracellular matrix. Overexpression of megsin results in an increase in number of mesangial cells and therefore a progressive mesangial matrix expansion, which is accompanied by immune complex deposition. This finding suggests that megsin significantly influences the role of mesangial cells in renal structure and is likely implicated in a variety of nephropathies. Alternative Name :
Serpin B7; Serpin-B7; Megsin; TP55 Swiss-Prot :
O75635 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide SERPINB7. (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS5794 SERPINB7 pAb.
Blocking peptide available as BS5794PP