HIPK2 Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
HIPK2 Peptide Applications :
Blocking Background :
The Homeodomain-Interacting Protein Kinase (HIPK) family, which includes HIPK1, HIPK2, HIPK3, contains a conserved protein kinase domain as well as a separate domain that interacts with homeoproteins. HIPK2, the most highly characterized family member, is thought to act as a co-repressor of homeodomain transcription factors as HIPK2 has been shown to enhance the DNA binding of the NK-3 homeoprotein in vitro. It is regulated by a posttranslational modification of a ubiquitin-like protein, SUMO-1, via covalent bonding to a lysine residue on HIPK2. This is similar to the binding of SUMO-1 to PML and Sp100. The conjugation of SUMO-1 is thought to direct each of these proteins to nuclear bodies (NBs), which appear to play a role in autoimmunity and viral protection. HIPK2 is the first protein kinase to be directed to nuclear bodies in response to ubiquitin-like modification. Alternative Name :
Homeodomain-interacting protein kinase 2; hHIPk2 Swiss-Prot :
Q9H2X6 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide HIPK2. (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS60320 HIPK2 pAb.
HIPK2 Peptide Applications :
Blocking Background :
The Homeodomain-Interacting Protein Kinase (HIPK) family, which includes HIPK1, HIPK2, HIPK3, contains a conserved protein kinase domain as well as a separate domain that interacts with homeoproteins. HIPK2, the most highly characterized family member, is thought to act as a co-repressor of homeodomain transcription factors as HIPK2 has been shown to enhance the DNA binding of the NK-3 homeoprotein in vitro. It is regulated by a posttranslational modification of a ubiquitin-like protein, SUMO-1, via covalent bonding to a lysine residue on HIPK2. This is similar to the binding of SUMO-1 to PML and Sp100. The conjugation of SUMO-1 is thought to direct each of these proteins to nuclear bodies (NBs), which appear to play a role in autoimmunity and viral protection. HIPK2 is the first protein kinase to be directed to nuclear bodies in response to ubiquitin-like modification. Alternative Name :
Homeodomain-interacting protein kinase 2; hHIPk2 Swiss-Prot :
Q9H2X6 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide HIPK2. (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS60320 HIPK2 pAb.
Blocking peptide available as BS60320PP