Na+ CP type VIIIα Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
Na+ CP type VIIIα Peptide Applications :
Blocking Background :
The sodium channel protein type 8 subunit alpha (Na+ CP type VIIIα ) is a multi-pass, transmembrane protein that mediates the sodium ion permeability of excitable membranes. The three glycoproteins that comprise the voltage-gated sodium channel proteins include a pore-forming α subunit, a noncovalently associated β1 subunit and a disulfide-linked β2 subunit. The two β subunits regulate the level of channel expression, modulate gating and function as cell adhesion molecules for cellular aggregation and cytoskeleton interaction. The α subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type IIα subunits are more abundant along axons. Sodium channels are important for rapid signal transduction but also play a significant role in neuronal development. Defects of the SCN8A gene have exhibited detrimental effects on the growth of secondary motoneurons. Loss of SCN8A expression will result in progressive paralysis and early death. Alternative Name :
Sodium channel protein type 8 subunit alpha; Sodium channel protein type VIII subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.6; SCN8A; MED Swiss-Prot :
Q9UQD0 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Na+ CP type VIIIα. (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS60365 Na+ CP type VIIIα pAb.
Na+ CP type VIIIα Peptide Applications :
Blocking Background :
The sodium channel protein type 8 subunit alpha (Na+ CP type VIIIα ) is a multi-pass, transmembrane protein that mediates the sodium ion permeability of excitable membranes. The three glycoproteins that comprise the voltage-gated sodium channel proteins include a pore-forming α subunit, a noncovalently associated β1 subunit and a disulfide-linked β2 subunit. The two β subunits regulate the level of channel expression, modulate gating and function as cell adhesion molecules for cellular aggregation and cytoskeleton interaction. The α subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type IIα subunits are more abundant along axons. Sodium channels are important for rapid signal transduction but also play a significant role in neuronal development. Defects of the SCN8A gene have exhibited detrimental effects on the growth of secondary motoneurons. Loss of SCN8A expression will result in progressive paralysis and early death. Alternative Name :
Sodium channel protein type 8 subunit alpha; Sodium channel protein type VIII subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.6; SCN8A; MED Swiss-Prot :
Q9UQD0 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Na+ CP type VIIIα. (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS60365 Na+ CP type VIIIα pAb.
Blocking peptide available as BS60365PP