ASM Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
ASM Peptide Applications :
Blocking Background :
Acid sphingomyelinase (ASM) is a lysosomal protein that hydrolyzes sphingomyelin to ceramide and phosphocholine. The ASM gene encodes three proteins, ASM-1, ASM-2 and ASM-3, of which ASM-1 is the only ASM gene product that is a catalytically active enzyme. Deficiency of ASM is associated with type A and type B Niemann-Pick disease. Type A is a fatal neurodegenerative disorder seen in infancy and resulting in death by age three, whereas type B is a non-neuropathic disease that has a later onset. During monocytic cell differentiation, the expression of ASM is upregulated by the combined actions of AP-2 and Sp1 transcription factors. Alternative Name :
Sphingomyelin phosphodiesterase; Acid sphingomyelinase; aSMase; SMPD1 Swiss-Prot :
P17405 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide ASM. (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS60373 ASM pAb.
ASM Peptide Applications :
Blocking Background :
Acid sphingomyelinase (ASM) is a lysosomal protein that hydrolyzes sphingomyelin to ceramide and phosphocholine. The ASM gene encodes three proteins, ASM-1, ASM-2 and ASM-3, of which ASM-1 is the only ASM gene product that is a catalytically active enzyme. Deficiency of ASM is associated with type A and type B Niemann-Pick disease. Type A is a fatal neurodegenerative disorder seen in infancy and resulting in death by age three, whereas type B is a non-neuropathic disease that has a later onset. During monocytic cell differentiation, the expression of ASM is upregulated by the combined actions of AP-2 and Sp1 transcription factors. Alternative Name :
Sphingomyelin phosphodiesterase; Acid sphingomyelinase; aSMase; SMPD1 Swiss-Prot :
P17405 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide ASM. (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS60373 ASM pAb.
Blocking peptide available as BS60373PP