Spasmolysin Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
Spasmolysin Peptide Applications :
Blocking Background :
Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing and protection of the gastrointestinal epithelia. These peptides contain three intrachain disulfide bonds, forming the trefoil motif, or P-domain. SP (spasmolytic polypeptide), also designated Trefoil factor 2 (TFF2) precursor, is a trefoil protein that functions to inhibit gastrointestinal motility and gastric acid secretion. SP may also act as a structural component of the gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. A downregulation of SP expression is associated with primary gastric cancer, and a progressive loss of this protein is likely to be involved in the early stage of the multi-step gastric carcinogenesis pathway. Alternative Name :
Trefoil factor 2; Spasmolysin; Spasmolytic polypeptide; SP; TFF2; SML1 Swiss-Prot :
Q03403 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Spasmolysin. (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS60387 Spasmolysin pAb.
Spasmolysin Peptide Applications :
Blocking Background :
Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing and protection of the gastrointestinal epithelia. These peptides contain three intrachain disulfide bonds, forming the trefoil motif, or P-domain. SP (spasmolytic polypeptide), also designated Trefoil factor 2 (TFF2) precursor, is a trefoil protein that functions to inhibit gastrointestinal motility and gastric acid secretion. SP may also act as a structural component of the gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. A downregulation of SP expression is associated with primary gastric cancer, and a progressive loss of this protein is likely to be involved in the early stage of the multi-step gastric carcinogenesis pathway. Alternative Name :
Trefoil factor 2; Spasmolysin; Spasmolytic polypeptide; SP; TFF2; SML1 Swiss-Prot :
Q03403 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Spasmolysin. (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS60387 Spasmolysin pAb.
Blocking peptide available as BS60387PP