DIAPH2 Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
DIAPH2 Peptide Applications :
Blocking Background :
Dia 1 (also designated p140mDia) and Dia 2 (also designated p134mDia 2), mammalian homologs of the Drosophila diaphanous gene, belong to a family of formin homology (FH) proteins which are characterized by having tandemly aligned FH1 and FH2 domains in their carboxy terminal regions. The amino terminus of inactivated Dia 1 binds to the FH1 and FH2 domains and is activated when GTP-bound Rho disrupts the intramolecular interaction of Dia 1 and converts it to an open conformation. Once activated, Dia 1 co-localizes with Profilin and RhoA in dynamic plasma membrane structures and induces the formation of stress fibers in conjunction with the ROCK-mediated signaling pathway. However, Dia 1 and ROCK activities antagonize each other in order to determine the thickness and density of the stress fibers formed. Alternative Name :
Protein diaphanous homolog 2; Diaphanous-related formin-2; DRF2; DIA; Diap2; Dia2; Dia 2 Swiss-Prot :
O60879 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide DIAPH2. (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS60413 DIAPH2 pAb.
DIAPH2 Peptide Applications :
Blocking Background :
Dia 1 (also designated p140mDia) and Dia 2 (also designated p134mDia 2), mammalian homologs of the Drosophila diaphanous gene, belong to a family of formin homology (FH) proteins which are characterized by having tandemly aligned FH1 and FH2 domains in their carboxy terminal regions. The amino terminus of inactivated Dia 1 binds to the FH1 and FH2 domains and is activated when GTP-bound Rho disrupts the intramolecular interaction of Dia 1 and converts it to an open conformation. Once activated, Dia 1 co-localizes with Profilin and RhoA in dynamic plasma membrane structures and induces the formation of stress fibers in conjunction with the ROCK-mediated signaling pathway. However, Dia 1 and ROCK activities antagonize each other in order to determine the thickness and density of the stress fibers formed. Alternative Name :
Protein diaphanous homolog 2; Diaphanous-related formin-2; DRF2; DIA; Diap2; Dia2; Dia 2 Swiss-Prot :
O60879 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide DIAPH2. (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS60413 DIAPH2 pAb.
Blocking peptide available as BS60413PP