Cleaved-Notch 2 (D1733) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
Cleaved-Notch 2 (D1733) Peptide Applications :
Blocking Background :
The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. To date, four Notch homologs have been identified in mammals and have been designated Notch 1, Notch 2, Notch 3 and Notch 4. The Notch genes are expressed in a variety of tissues in both the embryonic and adult organism, suggesting that the genes are involved in multiple signaling pathways. The Notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for Notch include Jagged, Jagged2 and Delta. Jagged can activate Notch and prevent myoblast differentiation by inhibiting the expression of muscle regulatory and structural genes. Jagged2 is thought to be involved in the development of various tissues whose development is dependent upon epithelial-mesenchymal interactions. Alternative Name :
Neurogenic locus notch homolog protein 2; Notch 2; hN2; Notch 2 extracellular truncation; Notch 2 intracellular domain; NOTCH2 Swiss-Prot :
Q04721 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Cleaved-Notch 2 (D1733). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS7015 Cleaved-Notch 2 (D1733) pAb.
Cleaved-Notch 2 (D1733) Peptide Applications :
Blocking Background :
The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. To date, four Notch homologs have been identified in mammals and have been designated Notch 1, Notch 2, Notch 3 and Notch 4. The Notch genes are expressed in a variety of tissues in both the embryonic and adult organism, suggesting that the genes are involved in multiple signaling pathways. The Notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for Notch include Jagged, Jagged2 and Delta. Jagged can activate Notch and prevent myoblast differentiation by inhibiting the expression of muscle regulatory and structural genes. Jagged2 is thought to be involved in the development of various tissues whose development is dependent upon epithelial-mesenchymal interactions. Alternative Name :
Neurogenic locus notch homolog protein 2; Notch 2; hN2; Notch 2 extracellular truncation; Notch 2 intracellular domain; NOTCH2 Swiss-Prot :
Q04721 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Cleaved-Notch 2 (D1733). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS7015 Cleaved-Notch 2 (D1733) pAb.
Blocking peptide available as BS7015PP