Product Name :
Cleaved-Notch 1 (V1754) Peptide Applications :
Blocking Background :
Notch1 is a transmembrane protein functioning in development and the determination of cell fate. During maturation, the notch molecule is cleaved by a furin-like convertase at its extracellular domain. Upon binding to a ligand such as Delta1, or upon extracellular calcium depletion, the carboxy-terminal notch1 fragment is released and further cleaved between Gly1753 and Val1754. The resulting activated cytosolic fragment translocates to the nucleus where it activates transcription. Alternative Name :
Notch1 intracellular domain NICD Swiss-Prot :
P46531 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Cleaved-Notch 1 (V1754). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS7018 Cleaved-Notch 1 (V1754) pAb.

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Blocking peptide available as BS7018 PP