Cleaved-PARP-1 (G215) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
Cleaved-PARP-1 (G215) Peptide Applications :
Blocking Background :
PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress. This protein can be cleaved by many ICE-like caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa). PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis. Alternative Name :
PARP1; ADPRT; PPOL; ADPRT 1; ARTD1; Poly [ADP-ribose] polymerase 1; ADP-ribosyltransferase diphtheria toxin-like 1 Swiss-Prot :
P09874 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Cleaved-PARP-1 (G215). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS7045 Cleaved-PARP-1 (G215) pAb.
Cleaved-PARP-1 (G215) Peptide Applications :
Blocking Background :
PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress. This protein can be cleaved by many ICE-like caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa). PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis. Alternative Name :
PARP1; ADPRT; PPOL; ADPRT 1; ARTD1; Poly [ADP-ribose] polymerase 1; ADP-ribosyltransferase diphtheria toxin-like 1 Swiss-Prot :
P09874 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Cleaved-PARP-1 (G215). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS7045 Cleaved-PARP-1 (G215) pAb.
Blocking peptide available as BS7045PP