Hox-B4 (A135) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
Hox-B4 (A135) Peptide Applications :
Blocking Background :
The homeobox genes encode a family of transcription factors that regulate development and postnatal tissue homeostasis. Encoded by the HOXB4 gene, the nuclear phosphoprotein HoxB4 plays a key role in regulating the balance between hematopoietic stem cell renewal and differentiation. Hematopoietic expression of HoxB4 is regulated by the binding of USF-1 and USF-2, the binding of which may be favored by cytokines promoting stem cell self-renewal versus differentiation. HoxB4 is dependent on AP-1 expression to induce changes in cellular proliferation and differentiation, which increases the levels of cyclin D1, thereby linking HoxB4 with key elements of the cell cycle machinery. HoxB4 also participates in the downregulation of c-Myc expression. It is expressed in developing hair follicles as well as in K-562 and HL-60 cells. Alternative Name :
Homeobox protein Hox-B4; Homeobox protein Hox-2.6; Homeobox protein Hox-2F; HOX2F; HOXB4 Swiss-Prot :
P17483 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Hox-B4 (A135). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS9018 Hox-B4 (A135) pAb.
Hox-B4 (A135) Peptide Applications :
Blocking Background :
The homeobox genes encode a family of transcription factors that regulate development and postnatal tissue homeostasis. Encoded by the HOXB4 gene, the nuclear phosphoprotein HoxB4 plays a key role in regulating the balance between hematopoietic stem cell renewal and differentiation. Hematopoietic expression of HoxB4 is regulated by the binding of USF-1 and USF-2, the binding of which may be favored by cytokines promoting stem cell self-renewal versus differentiation. HoxB4 is dependent on AP-1 expression to induce changes in cellular proliferation and differentiation, which increases the levels of cyclin D1, thereby linking HoxB4 with key elements of the cell cycle machinery. HoxB4 also participates in the downregulation of c-Myc expression. It is expressed in developing hair follicles as well as in K-562 and HL-60 cells. Alternative Name :
Homeobox protein Hox-B4; Homeobox protein Hox-2.6; Homeobox protein Hox-2F; HOX2F; HOXB4 Swiss-Prot :
P17483 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Hox-B4 (A135). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS9018 Hox-B4 (A135) pAb.
Blocking peptide available as BS9018PP