VRK3 (I179) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
VRK3 (I179) Peptide Applications :
Blocking Background :
The vaccinia-related kinase (VRK) proteins consist of three Ser-Thr kinases, designated VRK1, VRK2 and VRK3. In the human kinome, VKR proteins function as upstream regulators of several transcription factors. VRK3 (vaccinia related kinase 3) is a 474 amino acid nuclear protein that contains one protein kinase domain and belongs to the serine/threonine protein kinase family. Widely expressed in human tissues, VRK3 is thought to regulate ERK (extracellular signal regulated kinases) activity by directly binding to MPKs (mitogenactivated protein kinase phosphatases), specifically vaccinia H1-related (VHR) phosphatase, thereby dephosphorylating and inactivaing ERK in the nucleus. VRK3 exists as two alternatively spliced variants and is encoded by a gene located on human chromosome 19, which consists of around 63 million bases, over 1,400 genes and makes up over 2% of human genomic DNA. Alternative Name :
Inactive serine/threonine-protein kinase VRK3; Vaccinia-related kinase 3; VRK3 Swiss-Prot :
Q8IV63 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide VRK3 (I179). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS9200 VRK3 (I179) pAb.
VRK3 (I179) Peptide Applications :
Blocking Background :
The vaccinia-related kinase (VRK) proteins consist of three Ser-Thr kinases, designated VRK1, VRK2 and VRK3. In the human kinome, VKR proteins function as upstream regulators of several transcription factors. VRK3 (vaccinia related kinase 3) is a 474 amino acid nuclear protein that contains one protein kinase domain and belongs to the serine/threonine protein kinase family. Widely expressed in human tissues, VRK3 is thought to regulate ERK (extracellular signal regulated kinases) activity by directly binding to MPKs (mitogenactivated protein kinase phosphatases), specifically vaccinia H1-related (VHR) phosphatase, thereby dephosphorylating and inactivaing ERK in the nucleus. VRK3 exists as two alternatively spliced variants and is encoded by a gene located on human chromosome 19, which consists of around 63 million bases, over 1,400 genes and makes up over 2% of human genomic DNA. Alternative Name :
Inactive serine/threonine-protein kinase VRK3; Vaccinia-related kinase 3; VRK3 Swiss-Prot :
Q8IV63 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide VRK3 (I179). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS9200 VRK3 (I179) pAb.
Blocking peptide available as BS9200PP