HDAC1 (E417) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
HDAC1 (E417) Peptide Applications :
Blocking Background :
Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (for p300/CBP-associated factor), p300/CBP and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated mammalian RPD3) and HDAC3, all of which are related to the yeast transcriptional regulator Rpd3p, have been identified as histone deacetylases. Alternative Name :
Histone deacetylase 1; HD1; RPD3L1 Swiss-Prot :
Q13547 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide HDAC1 (E417). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS9235 HDAC1 (E417) pAb.
HDAC1 (E417) Peptide Applications :
Blocking Background :
Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (for p300/CBP-associated factor), p300/CBP and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated mammalian RPD3) and HDAC3, all of which are related to the yeast transcriptional regulator Rpd3p, have been identified as histone deacetylases. Alternative Name :
Histone deacetylase 1; HD1; RPD3L1 Swiss-Prot :
Q13547 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide HDAC1 (E417). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS9235 HDAC1 (E417) pAb.
Blocking peptide available as BS9235PP