Gab 2 (R270) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
Gab 2 (R270) Peptide Applications :
Blocking Background :
Critical components of this process include adapter protein such as Shc, IRS-1 and Gab 1 (GRB-associated binder-1) that lack detectable catalytic activity. These are immediate substrates of receptor tyrosine kinase activity and serve to link activated receptors to downstream signaling components. Whereas Shc has been implicated in signaling by diverse receptor families, IRS-1 serves primarily as the major Insulin receptor substrate. Shc and Gab 1 also participate in Insulin signaling by linking the Insulin receptor to Ras by forming complexes with GRB2 (another adapter protein) and Sos independently of IRS-1. The Gap 1 related protein, Gab 2, associates with SH2 domain-containing proteins, such as SHP2, and it is involved in a novel pathway for cytokine-induced gene activation. Alternative Name :
GAB 2; Grb 2 associated binder 2; GRB 2 associated binding protein 2; Grb2 associated binder 2; GRB2 associated binder 2 pp100; GRB2 associated binder 2 pp100; GRB2 associated binding protein 2; Growth factor receptor bound protein 2 associated protein 2; KIAA0571; p97; PH domain containing adaptor molecule p97; pp100; Swiss-Prot :
Q9UQC2 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Gab 2 (R270). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS9263 Gab 2 (R270) pAb.
Gab 2 (R270) Peptide Applications :
Blocking Background :
Critical components of this process include adapter protein such as Shc, IRS-1 and Gab 1 (GRB-associated binder-1) that lack detectable catalytic activity. These are immediate substrates of receptor tyrosine kinase activity and serve to link activated receptors to downstream signaling components. Whereas Shc has been implicated in signaling by diverse receptor families, IRS-1 serves primarily as the major Insulin receptor substrate. Shc and Gab 1 also participate in Insulin signaling by linking the Insulin receptor to Ras by forming complexes with GRB2 (another adapter protein) and Sos independently of IRS-1. The Gap 1 related protein, Gab 2, associates with SH2 domain-containing proteins, such as SHP2, and it is involved in a novel pathway for cytokine-induced gene activation. Alternative Name :
GAB 2; Grb 2 associated binder 2; GRB 2 associated binding protein 2; Grb2 associated binder 2; GRB2 associated binder 2 pp100; GRB2 associated binder 2 pp100; GRB2 associated binding protein 2; Growth factor receptor bound protein 2 associated protein 2; KIAA0571; p97; PH domain containing adaptor molecule p97; pp100; Swiss-Prot :
Q9UQC2 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Gab 2 (R270). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS9263 Gab 2 (R270) pAb.
Blocking peptide available as BS9263PP