IL-13R/CD213a1 Recombinant Protein 
Datasheet
COA
MSDS
SHIP
Product Name :
IL-13R/CD213a1 Recombinant Protein Swiss-Prot :
P78552 Host :
E.coli Tag :
≥0.5mg/ml Amino acid Sequence :
GGGGAAPTETQPPVTNLSVSVENLCTVIWTWNPPEGASSNCSLWYFSHFGDKQDKKIAPETRRSIEVPLNERICLQVGSQCSTNESEKPSILVEKCISPPEGDPESAVTELQCIWHNLSYMKCSWLPGRNTSPDTNYTLYYWHRSLEKIHQCENIFREGQYFGCSFDLTKVKDSSFEQHSVQIMVKDNAGKIKPSFNIVPLTSRVKPDPPHIKNLSFHNDDLYVQWENPQNFISRCLFYEVEVNNSQTETHNVFYVQEAKCENPEFERNVENTSCFMVPGVLPDTLNTVRIRVKTNKLCYEDDKLWSNWSQEMSIGKKRNST Restriction sites :
NdeI-XhoI Background :
The Th2 cytokine Interleukin-13 (IL-13) plays a critical role in allergen-induced airway hyper-responsiveness (AHR). Two different receptors exist for IL-13, designated IL-13Ra1 and 2. IL-13Ra1 exists as a heterodimer of IL-13Ra1 and IL-4Ra as a signaling subunit, whereas IL-13Ra2 acts as a decoy receptor for IL-13. Furthermore, TNFa or IL-4 stimulation induces IL-13Ra2 upregulation, while IL-13Ra1 is constitutively expressed. Cell surface localization of IL-13Ra2 abrogates IL-13 signaling, thus IL-13 induced translocation of the receptor from the cytoplasm provides a mechanism for negative-feedback of IL-13 signaling. IL-13Ra1 expression is predominant in B cells, monocytes and T cells, whereas IL-13Ra2 expression is highest in glioma cells. Soluble :
PBS, 4M Urea, PH7.4 Purification&Purity :
Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Expression vector :
pet-22b(+) BiowMW :
~35kDa Note :
For research use only, not for use in diagnostic procedure. concentration :
≥0.5mg/ml
IL-13R/CD213a1 Recombinant Protein Swiss-Prot :
P78552 Host :
E.coli Tag :
≥0.5mg/ml Amino acid Sequence :
GGGGAAPTETQPPVTNLSVSVENLCTVIWTWNPPEGASSNCSLWYFSHFGDKQDKKIAPETRRSIEVPLNERICLQVGSQCSTNESEKPSILVEKCISPPEGDPESAVTELQCIWHNLSYMKCSWLPGRNTSPDTNYTLYYWHRSLEKIHQCENIFREGQYFGCSFDLTKVKDSSFEQHSVQIMVKDNAGKIKPSFNIVPLTSRVKPDPPHIKNLSFHNDDLYVQWENPQNFISRCLFYEVEVNNSQTETHNVFYVQEAKCENPEFERNVENTSCFMVPGVLPDTLNTVRIRVKTNKLCYEDDKLWSNWSQEMSIGKKRNST Restriction sites :
NdeI-XhoI Background :
The Th2 cytokine Interleukin-13 (IL-13) plays a critical role in allergen-induced airway hyper-responsiveness (AHR). Two different receptors exist for IL-13, designated IL-13Ra1 and 2. IL-13Ra1 exists as a heterodimer of IL-13Ra1 and IL-4Ra as a signaling subunit, whereas IL-13Ra2 acts as a decoy receptor for IL-13. Furthermore, TNFa or IL-4 stimulation induces IL-13Ra2 upregulation, while IL-13Ra1 is constitutively expressed. Cell surface localization of IL-13Ra2 abrogates IL-13 signaling, thus IL-13 induced translocation of the receptor from the cytoplasm provides a mechanism for negative-feedback of IL-13 signaling. IL-13Ra1 expression is predominant in B cells, monocytes and T cells, whereas IL-13Ra2 expression is highest in glioma cells. Soluble :
PBS, 4M Urea, PH7.4 Purification&Purity :
Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Expression vector :
pet-22b(+) BiowMW :
~35kDa Note :
For research use only, not for use in diagnostic procedure. concentration :
≥0.5mg/ml
Blocking peptide available as NCP0238P